Gene causing diabetes, low blood sugar levels identified

Besides Type 1 or Type 2 diabetes, nearly 1-2 per cent of cases of the blood sugar condition is due to impairment in a gene called MAFA, that can impair production of insulin and also cause insulinomas - insulin-producing tumours in pancreas, the study showed.

IANS
London, Publish Date: Jan 16 2018 4:49PM | Updated Date: Jan 16 2018 4:49PM
Gene causing diabetes, low blood sugar levels identifiedFile Photo

Researchers have identified a new gene that is thought to be critical in the regulation of insulin -- the key hormone in diabetes -- from a family with both high and low blood sugar conditions.

Besides Type 1 or Type 2 diabetes, nearly 1-2 per cent of cases of the blood sugar condition is due to impairment in a gene called MAFA, that can impair production of insulin and also cause insulinomas -- insulin-producing tumours in pancreas, the study showed.

Insulinomas tumours are typically caused by low blood sugar levels, in contrast to diabetes which leads to high blood sugar levels.

"We were initially surprised about the association of two apparently contrasting conditions within the same families -- diabetes which is associated with high blood sugar and insulinomas associated with low blood sugar," said lead author Marta Korbonits, Professor at the Queen Mary University of London (QMUL).

"Our research shows that, surprisingly, the same gene defect can impact the insulin-producing beta cells of the pancreas to lead to these two opposing medical conditions," Korbonits added.

The study, published in the journal PNAS, also observed that males were more prone to developing diabetes, while insulinomas were more commonly found in females, but the reasons behind this difference are as yet unknown.

This is the first time a defect in MAFA gene has been linked with a disease. The resultant mutant protein was found to be abnormally stable, having a longer life in the cell, and therefore significantly more abundant in the beta cells than its normal version.

For the study, the team examined the unique case of a family where several individuals suffered from diabetes, while other members developed insulinomas in their pancreas. 

 

Latest News

  1. Specially-abled man from Bihar reunited with family after 18 years: Police
  2. Specially-abled man from Bihar reunited with family after 18 years: Police
  1. Two army men injured in Pulwama grenade attack
  2. Two army men injured in Pulwama grenade attack
  1. Forces launch CASO in Pulwama village after grenade attack, firing
  2. Forces launch CASO in Pulwama village after grenade attack, firing
  1. BJP front-runner in Jammu civic polls, Congress ahead in Kashmir valley
  2. BJP front-runner in Jammu civic polls, Congress ahead in Kashmir valley
  1. Bandipora woman death: Husband, in-laws booked for abetment to suicide
  2. Bandipora woman death: Husband, in-laws booked for abetment to suicide
  1. BJP leading in JMC elections, independents fare well in Kishtwar
  2. BJP leading in JMC elections, independents fare well in Kishtwar
  1. World’s longest sea bridge between China-Hong Kong to open on October 24
  2. World’s longest sea bridge between China-Hong Kong to open on October 24
  1. Khashoggi death: don't give Saudi Arabia 'licence to kill', says RSF
  2. Khashoggi death: don't give Saudi Arabia 'licence to kill', says RSF
  1. Landslide blocks Kashmir highway in Ramsoo
  2. Landslide blocks Kashmir highway in Ramsoo
  1. Man who played Ravana killed after saving several lives in Punjab train accident
  2. Man who played Ravana killed after saving several lives in Punjab train accident
  1. Man 'stoned to death by monkeys', family wants FIR to be registered against them
  2. Man 'stoned to death by monkeys', family wants FIR to be registered against them
  1. Independents bag all 13 wards of Kupwara municipal body
  2. Independents bag all 13 wards of Kupwara municipal body
  1. Local bodies’ elections in Kashmir only a ‘sham’: Saifuddin Soz
  2. Local bodies’ elections in Kashmir only a ‘sham’: Saifuddin Soz
  1. KCCI cites Internet blockade, seeks extension in filing GST returns
  2. KCCI cites Internet blockade, seeks extension in filing GST returns
  1. SMC polls: Former Congress MP Tariq Karra's wife loses from Ward 31
  2. SMC polls: Former Congress MP Tariq Karra's wife loses from Ward 31
  1. Multiple blasts rock Kabul polling stations: official, witnesses
  2. Multiple blasts rock Kabul polling stations: official, witnesses
  1. JK polls: BJP fails to open account in Ladakh region
  2. JK polls: BJP fails to open account in Ladakh region
  1. Minister denies Railways' lapse in Amritsar tragedy
  2. Minister denies Railways' lapse in Amritsar tragedy
  1. Amritsar survivors, families recall night of horror
  2. Amritsar survivors, families recall night of horror
  1. North Korean hacker group stole $571 mn in crypto attacks
  2. North Korean hacker group stole $571 mn in crypto attacks
  1. Delhi court frames molestation charges against R K Pachauri
  2. Delhi court frames molestation charges against R K Pachauri
  1. Civic polls: BJP emerges winner in four south Kashmir districts, set to control four municipal bodies
  2. Civic polls: BJP emerges winner in four south Kashmir districts, set to control four municipal bodies
  1. Congress party gets majority in two municipal committees in Bandipora in north Kashmir
  2. Congress party gets majority in two municipal committees in Bandipora in north Kashmir
  1. Independents sweep Handwara municipal body polls results
  2. Independents sweep Handwara municipal body polls results
  1. Baramulla Municipal council: Congress wins 12 seats, BJP 6
  2. Baramulla Municipal council: Congress wins 12 seats, BJP 6
  1. Municipal committee Ganderbal: Independents win 13 wards; BJP, Congress win 2 each
  2. Municipal committee Ganderbal: Independents win 13 wards; BJP, Congress win 2 each
  1. Ramban municipal committee polls: Congress, BJP and Independents win two wards each
  2. Ramban municipal committee polls: Congress, BJP and Independents win two wards each
  1. Kokernag municipal committee polls: Congress wins ten wards
  2. Kokernag municipal committee polls: Congress wins ten wards
  1. Kerala MLA Abdul Razak dies of heart attack
  2. Kerala MLA Abdul Razak dies of heart attack
  1. Mattan municipal committee polls: BJP wins 7, Congress two wards
  2. Mattan municipal committee polls: BJP wins 7, Congress two wards
  1. Banihal municipal committee: Congress wins all four wards, BJP draws blank
  2. Banihal municipal committee: Congress wins all four wards, BJP draws blank
  1. Kargil municipal committee: Congress wins 5, Independents 8 wards
  2. Kargil municipal committee: Congress wins 5, Independents 8 wards
  1. Congress wins all 13 wards of Leh municipal committee, BJP draws blank
  2. Congress wins all 13 wards of Leh municipal committee, BJP draws blank
  1. Congress wins 20 out of 25 wards in Anantnag municipal council
  2. Congress wins 20 out of 25 wards in Anantnag municipal council
  1. BJP candidate gets 8 out of nine votes, wins ward 74 of Srinagar Municipal Corporation
  2. BJP candidate gets 8 out of nine votes, wins ward 74 of Srinagar Municipal Corporation
  1. US 'saddened' by confirmed Khashoggi death: White House
  2. US 'saddened' by confirmed Khashoggi death: White House
  1. Police begin probe as train mows down 58 Dussehra revellers in Punjab
  2. Police begin probe as train mows down 58 Dussehra revellers in Punjab
  1. Khashoggi died in fight at consulate, admits Saudi Arabia
  2. Khashoggi died in fight at consulate, admits Saudi Arabia
  1. Counting begins for Jammu and Kashmir municipal polls
  2. Counting begins for Jammu and Kashmir municipal polls
x
This site uses cookies to deliver our services and to show you relevant news and ads. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Service.That's Fine